Apply Now: Gates Foundation Low-Cost Nutrients Challenge – Grand Challenges 2025

The Bill & Melinda Gates Foundation, via the Grand Challenges Initiative, invites innovators, organizations, and establishments worldwide to apply for a brand new funding alternative geared toward remodeling maternal and child diet in low- and middle-income international locations (LMICs).

This name seeks daring, scalable improvements that can dramatically cut back the price of important nutrient elements and prenatal dietary supplements—making certain that each mom and child, no matter the place they dwell, can entry the vitamins wanted to outlive and thrive.

Malnutrition stays one of the crucial extreme threats to maternal and child well being in LMICs. Nutrient deficiencies throughout being pregnant and the primary 1,000 days of life can result in irreversible developmental challenges, larger mortality, lowered productiveness, and long-term well being points.

Although confirmed diet interventions exist, excessive manufacturing prices and restricted manufacturing capability make many nutrient merchandise unaffordable in susceptible areas. The vitamins prioritized on this problem are:

Despite sturdy international suggestions from WHO, EFSA, AAP, and different authorities, many pregnant ladies worldwide are unable to fulfill really useful consumption ranges on account of price obstacles.

---

About the Low-Cost Nutrients Challenge

This initiative requires transformative options—not incremental modifications. Applicants are anticipated to suggest improvements that cut back nutrient ingredient or product prices by not less than 50% whereas sustaining excessive requirements of security, stability, and client acceptability.

Projects could goal enhancements in:

The purpose is to create sustainable, inexpensive diet options suited to LMIC well being programs.

---

Focus Areas (Apply Under One Option)

Option A: Exceptionally Low-Cost Nutrient Ingredients

Develop low-cost variations of calcium, choline, or DHA elements.
Requirements:

• ≥50% price discount from present lowest market costs

• Meet pharmacopeial requirements & ICH Q7 GMP

• Stable, allergen-free, and culturally inclusive (halal, kosher, vegetarian)

Option B: Low-Cost Prenatal Supplement (UNIMMAP + Calcium)

Develop a prenatal complement costing lower than US$2 per 180-day routine.
Requirements:

• Informed by client analysis

• 3-month real-time and 6-month accelerated stability (ICH Q1 Zone IVb)

• Preferably WHO-GMP compliant

Option C: Advanced Prenatal Supplement (MMSplus)

Formulate a sophisticated prenatal complement together with:

---

Funding Levels

Indirect prices mustn’t exceed 10–15% of the whole price range.

---

Eligibility

The problem is open globally to:

Applicants should apply via a legally acknowledged company entity. Collaboration with LMIC companions is strongly inspired.

---

What Successful Proposals Should Demonstrate

Successful proposals will display daring considering, technical rigor, and a pathway to scale. Specifically, we’re in search of proposals that can:

• Transformative cost-reduction methods (≥50%)

• Clear technical roadmap and feasibility

• Scalable options supported by price modelling (e.g., 3 million regimens/yr)

• Strong group experience

• Consideration for LMIC manufacturing and cultural inclusivity

• Consumer-informed product design

• Realistic and justified budgets

We encourage candidates to establish and construct collaborations with organizations that convey complementary experience. Where acceptable, the Foundation could facilitate connections amongst candidates engaged on associated challenges

---

What Will Not Be Funded

Proposals based mostly on the next is not going to be funded:

• Procurement or bulk buying methods

• Minor, incremental enhancements

• Delivery fashions with out product innovation

• Nutrients/merchandise exterior the required scope

---

Open Date: October 27, 2025

Application Deadline: December 16, 2025

---

How to Apply

Apply via this  LINK

For extra details about the job, click on  HERE

Related